Adverse events have not been observed in animal reproduction studies. Amoxicillin crosses the placenta. Maternal use of amoxicillin has generally not resulted in an increased risk of adverse fetal effects; however, a possible association with cleft lip with cleft palate has been observed in some studies.
Amoxicillin is excreted in breast milk. Caution be exercised when administering amoxicillin to nursing women.